Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis

0484778 - ÚFE 2018 RIV CH eng J - Journal Article
Kalousová, M. - Dusilová-Sulková, S. - Kuběna, A.A. - Zakiyanov, O. - Levová, K. - Bocková, Markéta - Gedeonová, Erika - Chadtová Song, Xue - Ermini, Maria Laura - Špringer, Tomáš - Homola, Jiří - Tesař, V. - Zima, T.
Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis.
Kidney & Blood Pressure Research. Roč. 42, č. 3 (2017), s. 509-518. ISSN 1420-4096. E-ISSN 1423-0143
R&D Projects: GA ČR(CZ) GBP205/12/G118
Grant - others:AV ČR(CZ) AP1101
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:67985882
Keywords : Surface plasmon resonance * Hemodialysis * Infection * Mortality
OECD category: Biochemistry and molecular biology
Impact factor: 3.000, year: 2017

Background: Pregnancy-associated plasma protein A (PAPP-A) is associated with adverse outcome of long-term hemodialysis patients (HD). The aim of the study was to test whether its homolog pregnancy-associated plasma protein A2 (PAPP-A2) can be detected in serum of HD patients and to define its significance. Methods: The studied group consisted of 102 long-term HD patients and 25 healthy controls. HD patients were prospectively followed up for five years (2009-2014). PAPP-A2 was measured by surface plasmon resonance biosensor, PAPP-A by time resolved amplified cryptate emission. Results: PAPP-A2, similarly as PAPP-A, was significantly increased in HD patients (median (interquartile range)) PAPP-A2: 6.2 (2.6-10.8) ng/mL, vs. 3.0 (0.7-5.9) ng/mL, p=0.006, PAPP-A: 18.9 (14.3-23.4) mIU/L, vs. 9.5 (8.4-10.5) mIU/L, p < 0.001). In HD patients, PAPP-A2 correlated weakly but significantly with PAPP-A (tau=0.193, p=0.004). Unlike PAPP-A, PAPP-A2 was not significant for prognosis of HD patients when tested alone. There was a significant interaction between PAPP-A and PAPP-A2 on the mortality due to infection of HD patients (p=0.008). If PAPP-A was below median, mortality due to infection was significantly higher for patients with PAPP-A2 values above median than for patients with low PAPP-A2 levels (p=0.011). Conclusion: PAPP-A2 is increased in HD patients and interacts with PAPP-A on patients´prognosis
Permanent Link: http://hdl.handle.net/11104/0279923