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Ion Source with Laser Triangulation for Ambient Mass Spectrometry of Nonplanar Samples
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SYSNO ASEP 0482600 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ion Source with Laser Triangulation for Ambient Mass Spectrometry of Nonplanar Samples Author(s) Rejšek, Jan (UOCHB-X)
Vrkoslav, Vladimír (UOCHB-X) RID, ORCID
Pokorný, Vít (UOCHB-X)
Přibyl, Vladimír (UOCHB-X)
Cvačka, Josef (UOCHB-X) RID, ORCIDSource Title Analytical Chemistry. - : American Chemical Society - ISSN 0003-2700
Roč. 89, č. 21 (2017), s. 11452-11459Number of pages 8 s. Language eng - English Country US - United States Keywords desorption electrospray ionization ; atmospheric pressure photoionization ; metabolites Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry Institutional support UOCHB-X - RVO:61388963 UT WOS 000414887000043 DOI 10.1021/acs.analchem.7b02568 Annotation The analysis of nonplanar samples in ambient mass spectrometry poses a formidable challenge. Here, an ion source equipped with laser triangulation for analyzing nonplanar surfaces was constructed. It was designed as a two-position device, where the sample height was measured using laser triangulation and the target compounds were then analyzed. Thanks to a stage movable in xyz, the ion source maintained an optimal vertical distance between the sample and the sampling capillary for each measured spot during the surface analysis. The xyz-coordinates for the movement of the sample stage were computed using the laser sensor data in such a way as to avoid direct contact of the sampling capillary and the measured surface. The ion source performance and its ability to analyze various morphologies were tested using desorption electrospray ionization with plastic objects coated by 2,5-dimethoxybenzoic acid. The experiments showed excellent performance for nonplanar samples but also revealed some limitations especially on object edges and steep slopes. The applicability of the ion source operated in desorption electrospray ionization and desorption atmospheric pressure photoionization was examined for food and pharmaceutical samples. Chemicals on the surface of nonplanar samples were probed along a line extending across the surface of the measured objects. The device provided high-quality spectra, regardless of the sample height at the measured spot. The automatic adjustments of the sample stage in xyz proved to be beneficial for analyzing nonplanar samples and for simultaneous measurement of samples with various dimensions and shapes. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2018
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