Number of the records: 1  

Transgenerational inheritance of susceptibility to diabetes-induced male subfertility

  1. 1.
    SYSNO ASEP0482594
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleTransgenerational inheritance of susceptibility to diabetes-induced male subfertility
    Author(s) Pavlínková, Gabriela (BTO-N) RID, ORCID
    Margaryan, Hasmik (BTO-N) RID
    Žatecká, Eva (BTO-N)
    Valášková, Eliška (BTO-N)
    Elzeinová, Fatima (BTO-N) RID
    Kubátová, Alena (BTO-N) RID
    Bohuslavová, Romana (BTO-N) RID
    Pěknicová, Jana (BTO-N) RID
    Number of authors8
    Article number4940
    Source TitleScientific Reports. - : Nature Publishing Group - ISSN 2045-2322
    Roč. 7, JUL 10 2017 (2017)
    Number of pages14 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsHIGH-FAT DIET ; MALE-INFERTILITY ; GENE-EXPRESSION ; SPERM PARAMETERS
    Subject RIVFB - Endocrinology, Diabetology, Metabolism, Nutrition
    OECD categoryEndocrinology and metabolism (including diabetes, hormones)
    R&D ProjectsNV15-30880A GA MZd - Ministry of Health (MZ)
    GA16-06825S GA ČR - Czech Science Foundation (CSF)
    ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportBTO-N - RVO:86652036
    UT WOS000405180900013
    EID SCOPUS85034263302
    DOI https://doi.org/10.1038/s41598-017-05286-0
    AnnotationMale infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of diabetic males. The study was performed in streptozotocin-induced type 1 diabetes mouse model. Diabetes decreased sperm concentration and viability and increased sperm apoptosis. Changes in protamine 1/protamine 2 ratio indicated reduced sperm quality. The testicular tissue of diabetic males showed significant tissue damage, disruption of meiotic progression, and changes in the expression of genes encoding proteins important for spermiogenesis. Paternal diabetes altered sperm quality and expression pattern in the testes in offspring of two subsequent generations. Our study revealed that paternal diabetes increased susceptibility to infertility in offspring through gametic alternations. Our data also provide a mechanistic basis for transgenerational inheritance of diabetes-associated pathologies since protamines may be involved in epigenetic regulations.
    WorkplaceInstitute of Biotechnology
    ContactMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Year of Publishing2018
Number of the records: 1  

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