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Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish
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SYSNO ASEP 0481774 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish Author(s) Symonová, Radka (UZFG-Y) RID
Majtánová, Zuzana (UZFG-Y) RID, ORCID
Arias-Rodriquez, L. (MX)
Mořkovský, L. (CZ)
Kořínková, Tereza (UZFG-Y) RID
Cavin, L. (CH)
Johnson Pokorná, Martina (UZFG-Y) ORCID
Doležálková, Marie (UZFG-Y) RID, ORCID
Flajšhans, M. (CZ)
Normandeau, E. (CA)
Ráb, Petr (UZFG-Y) RID, ORCID
Meyer, A. (DE)
Bernatchez, L. (CA)Source Title Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. - : Wiley - ISSN 1552-5007
Roč. 328, č. 7 (2017), s. 607-619Number of pages 13 s. Publication form Print - P Language eng - English Country US - United States Keywords biased gene conversion ; cold-blooded vertebrates ; density gradient centrifugation Subject RIV EB - Genetics ; Molecular Biology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology R&D Projects GPP506/11/P596 GA ČR - Czech Science Foundation (CSF) GA14-02940S GA ČR - Czech Science Foundation (CSF) Institutional support UZFG-Y - RVO:67985904 UT WOS 000413586500003 EID SCOPUS 85007495631 DOI https://doi.org/10.1002/jez.b.22719 Annotation Genomic GC content can vary locally, and GC-rich regions are usually associated with increased DNA thermostability in thermophilic prokaryotes and warm-blooded eukaryotes. Among vertebrates, fish and amphibians appeared to possess a distinctly less heterogeneous AT/GC organization in their genomes, whereas cytogenetically detectable GC heterogeneity has so far only been documented in mammals and birds. The subject of our study is the gar, an ancient living fossil of a basal ray-finned fish lineage, known from the Cretaceous period. We carried out cytogenomic analysis in two gar genera (Atractosteus and Lepisosteus) uncovering a GC chromosomal pattern uncharacteristic for fish. Bioinformatic analysis of the spotted gar (Lepisosteus oculatus) confirmed a GC compartmentalization on GC profiles of linkage groups. This indicates a rather mammalian mode of compositional organization on gar chromosomes. Gars are thus the only analyzed extant ray-finned fishes with a GC compartmentalized genome. Since gars are cold-blooded anamniotes, our results contradict the generally accepted hypothesis that the phylogenomic onset of GC compartmentalization occurred near the origin of amniotes. Ecophysiological findings of other authors indicate a metabolic similarity of gars with mammals. We hypothesize that gars might have undergone convergent evolution with the tetrapod lineages leading to mammals on both metabolic and genomic levels. Their metabolic adaptations might have left footprints in their compositional genome evolution, as proposed by the metabolic rate hypothesis. The genome organization described here in gars sheds new light on the compositional genome evolution in vertebrates generally and contributes to better understanding of the complexities of the mechanisms involved in this process. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2018
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