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The silymarin composition ... and why does it matter???
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SYSNO ASEP 0481180 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The silymarin composition ... and why does it matter??? Author(s) Chambers, Christopher S. (MBU-M) RID, ORCID
Holečková, Veronika (MBU-M)
Petrásková, Lucie (MBU-M) ORCID
Biedermann, David (MBU-M) RID, ORCID
Valentová, Kateřina (MBU-M) RID, ORCID
Buchta, M. (CZ)
Křen, Vladimír (MBU-M) RID, ORCIDSource Title Food Research International. - : Elsevier - ISSN 0963-9969
Roč. 100, OCT 2017 (2017), s. 339-353Number of pages 15 s. Language eng - English Country NL - Netherlands Keywords Silymarin ; Flavonolignans ; Milk thistle Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA15-03037S GA ČR - Czech Science Foundation (CSF) NV16-27317A GA MZd - Ministry of Health (MZ) LD15081 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LD15082 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 UT WOS 000413388700004 DOI 10.1016/j.foodres.2017.07.017 Annotation The extract from milk thistle (Silybum mariamen (L.) Gaertn. (Asteraceae)), known as silymarin, contains a variety of flavonolignans and displays antioxidant, anti-inflammatory, immunomodulatory and hepatoprotective properties. As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. This leads to problems in reproducibility of scientific results, as the exact composition of silymarin is often unknown and can vary to a certain degree depending on the processing, chemovariety of the plant used and climatic conditions during the plant growth. There are studies dealing with the analytical separation and quantification of silymarin components as well as studies focused on silymarin content in clinically used drugs, in various plant parts, seasons, geographic locations etc. However, no comparison of detail flavonolignan profiles in various silymarin preparations is available to date. Also, as a result of the focus on the flavonolignans, the oil fraction, which contains linoleic, oleic and palmitic acids, sterols, tocopherol (vitamin E) and phospholipids, has been neglected. Due to all these factors, the whole plant is used e.g. as animal feed, the leaves can be eaten in salads and seed oil, besides culinary uses, can be also utilized for biodiesel or polymer production. Various HPLC separation techniques for the determination of the content of the flavonolignans have been vastly summarized in the present review. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2018
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