Number of the records: 1
Positive and Negative Signals in Mast Cell Activation
- 1.
SYSNO ASEP 0477931 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Positive and Negative Signals in Mast Cell Activation Author(s) Bulfone-Paus, S. (GB)
Nilsson, G. (SE)
Dráber, Petr (UMG-J) RID
Blank, U. (FR)
Levi-Schaffer, F. (IL)Number of authors 5 Source Title Trends in Immunology. - : Elsevier - ISSN 1471-4906
Roč. 38, č. 9 (2017), s. 657-667Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords fc-epsilon-ri ; receptor irp60 cd300a ; inhibitory receptor ; inflammatory responses ; allergic reactions ; tetraspanin cd9 ; human basophils ; ige repertoire ; host-defense ; in-vitro Subject RIV EB - Genetics ; Molecular Biology OECD category Immunology Institutional support UMG-J - RVO:68378050 UT WOS 000408362600006 DOI 10.1016/j.it.2017.01.008 Annotation Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel Fc epsilon RI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2018
Number of the records: 1