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New adenoviruses from new primate hosts - growing diversity reveals taxonomic weak points
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SYSNO ASEP 0475020 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title New adenoviruses from new primate hosts - growing diversity reveals taxonomic weak points Author(s) Dadáková, E. (CZ)
Chrudimský, Tomáš (BC-A) RID
Brožová, K. (CZ)
Modrý, David (BC-A) RID, ORCID
Celer, V. (CZ)
Hrazdilová, K. (CZ)Source Title Molecular Phylogenetics and Evolution. - : Elsevier - ISSN 1055-7903
Roč. 107, February (2017), s. 305-307Number of pages 3 s. Language eng - English Country US - United States Keywords adenovirus ; primate ; phylogeny ; taxonomy Subject RIV EE - Microbiology, Virology OECD category Microbiology Institutional support BC-A - RVO:60077344 UT WOS 000394200500029 EID SCOPUS 85001948848 DOI 10.1016/j.ympev.2016.11.013 Annotation The knowledge of the closest human relatives of human adenoviruses (AdVs) such as adenoviruses found in nonhuman primates is still limited, despite the growing importance of adenoviruses in vaccine development, gene and cancer therapy. We examined 153 stool samples of 17 non-human primate species and detected adenoviral DNA sequences of DNA polymerase (DPOL) gene in 54 samples (35%), originating from 12 out of 17 primate species. We further sequenced 15 hexon gene fragments and based on the phylogenetic analysis we propose two new provisional species SAdV-H and SAdV-I. Our study shows extensive diversity of adenoviral strains forming separate clades often from closely related host species from old world monkeys suggesting the existence of new species of AdVs and shows the necessity for clear ICTV guidelines for final establishment of so far provisional AdV species. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2018
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