Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

Javanainen, M.; Melcrová, Adéla; Magarkar, Aniket; Jurkiewicz, Piotr; Hof, Martin; Jungwirth, Pavel; Martinez-Seara, Hector

doi:https://dx.doi.org/10.1039/c7cc02208e

Number of the records: 1

Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

1.

SYSNO ASEP	0474712
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes
Author(s)	Javanainen, M. (FI) Melcrová, Adéla (UFCH-W) Magarkar, Aniket (UOCHB-X) Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Hof, Martin (UFCH-W)_{RID, ORCID} Jungwirth, Pavel (UOCHB-X)_{RID, ORCID} Martinez-Seara, Hector (UOCHB-X)_{RID, ORCID}
Source Title	Chemical Communications. - : Royal Society of Chemistry - ISSN 1359-7345 Roč. 53, č. 39 (2017), s. 5380-5383
Number of pages	4 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	phospholipid bilayers ; molecular dynamics ; fluorescence
Subject RIV	CF - Physical ; Theoretical Chemistry
OECD category	Physical chemistry
Subject RIV - cooperation	Institute of Organic Chemistry and Biochemistry - Physical ; Theoretical Chemistry
R&D Projects	GA17-03160S GA ČR - Czech Science Foundation (CSF)
	GA16-01074S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	UFCH-W - RVO:61388955 ; UOCHB-X - RVO:61388963
UT WOS	000401118400005
EID SCOPUS	85021689400
DOI	10.1039/c7cc02208e
Annotation	Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol—a key molecule inducing membrane heterogeneity—affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2018

Number of the records: 1