Number of the records: 1
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer
- 1.0473778 - BTÚ 2018 RIV US eng J - Journal Article
Rohlenová, Kateřina - Sachaphibulkij, K. - Stursa, J. - Bezawork-Geleta, A. - Blecha, Jan - Endaya, B. - Werner, L. - Černý, Jiří - Zobalová, Renata - Goodwin, J. - Špaček, Tomáš - Pesdar, E.A. - Yan, B. - Nguyen, M.N. - Vondrusová, Magdaléna - Sobol, Margaryta - Ježek, Petr - Hozák, Pavel - Truksa, Jaroslav - Rohlena, Jakub - Dong, L.F. - Neužil, Jiří
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer.
Antioxidants & Redox Signaling. Roč. 26, č. 2 (2017), s. 84-103. ISSN 1523-0864. E-ISSN 1557-7716
R&D Projects: GA ČR(CZ) GA16-12719S; GA ČR(CZ) GA16-22823S; GA ČR GA13-28830S; GA ČR(CZ) GA16-12816S; GA TA ČR(CZ) TE01020118; GA MPO FR-TI3/588; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036 ; RVO:67985823 ; RVO:68378050
Keywords : mitochondrially targeted tamoxifen * HER2 * respirasome
OECD category: Biochemistry and molecular biology; Oncology (FGU-C); Biochemistry and molecular biology (UMG-J)
Impact factor: 6.530, year: 2017
Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2(high) disease.
Permanent Link: http://hdl.handle.net/11104/0270919
Number of the records: 1