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Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza
- 1.0473216 - ÚMG 2017 RIV FR eng J - Journal Article
Albinana, C. B. - Machara, A. - Řezáčová, Pavlína - Pachl, P. - Konvalinka, J. - Kožíšek, M.
Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.
European Journal of Medicinal Chemistry. Roč. 121, OCT 4 (2016), s. 100-109. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:68378050
Keywords : Influenza neuraminidase * Oseltamivir * Tamiphosphor * Isothermal titration calorimetry * Crystal structure * Lattice-translocation defect
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.519, year: 2016
Influenza virus causes severe respiratory infections that are responsible for up to half a million deaths worldwide each year. Two inhibitors targeting viral neuraminidase have been approved to date (oseltamivir, zanamivir). However, the rapid development of antiviral drug resistance and the efficient transmission of resistant viruses among humans represent serious threats to public health.
Permanent Link: http://hdl.handle.net/11104/0270375
Number of the records: 1