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Gene-specific sex effects on eosinophil infiltration in leishmaniasis
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SYSNO ASEP 0472109 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Gene-specific sex effects on eosinophil infiltration in leishmaniasis Author(s) Slapničková, Martina (UMG-J)
Volkova, Valeriya (UMG-J)
Čepičková, Marie (UMG-J)
Kobets, Tetyana (UMG-J) RID
Šíma, Matyáš (UMG-J) ORCID
Svobodová, M. (CZ)
Demant, P. (US)
Lipoldová, Marie (UMG-J) RIDNumber of authors 8 Article number 59 Source Title Biology of Sex Differences . - : BioMed Central
Roč. 7, podzim (2016)Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords Leishmania major ; Mouse model ; Eosinophii infiltration ; Genetic control ; QTL ; Sex influence Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA14-30186S GA ČR - Czech Science Foundation (CSF) GP13-41002P GA ČR - Czech Science Foundation (CSF) LH12049 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA16-22346S GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 UT WOS 000389486900001 DOI 10.1186/s13293-016-0117-3 Annotation Background: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2017
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