Number of the records: 1  

Gene-specific sex effects on eosinophil infiltration in leishmaniasis

  1. 1.
    SYSNO ASEP0472109
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleGene-specific sex effects on eosinophil infiltration in leishmaniasis
    Author(s) Slapničková, Martina (UMG-J)
    Volkova, Valeriya (UMG-J)
    Čepičková, Marie (UMG-J)
    Kobets, Tetyana (UMG-J) RID
    Šíma, Matyáš (UMG-J) ORCID
    Svobodová, M. (CZ)
    Demant, P. (US)
    Lipoldová, Marie (UMG-J) RID
    Number of authors8
    Article number59
    Source TitleBiology of Sex Differences . - : BioMed Central
    Roč. 7, podzim (2016)
    Number of pages12 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsLeishmania major ; Mouse model ; Eosinophii infiltration ; Genetic control ; QTL ; Sex influence
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsGA14-30186S GA ČR - Czech Science Foundation (CSF)
    GP13-41002P GA ČR - Czech Science Foundation (CSF)
    LH12049 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    GA16-22346S GA ČR - Czech Science Foundation (CSF)
    Institutional supportUMG-J - RVO:68378050
    UT WOS000389486900001
    DOI10.1186/s13293-016-0117-3
    AnnotationBackground: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance.
    WorkplaceInstitute of Molecular Genetics
    ContactNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2017
Number of the records: 1  

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