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Decellularized Porcine Pericardium for Cardiovascular Tissue Engineering
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SYSNO ASEP 0471889 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Decellularized Porcine Pericardium for Cardiovascular Tissue Engineering Author(s) Marková, Marie (FGU-C)
Filová, Elena (FGU-C) RID, ORCID
Matějka, Roman (FGU-C) RID, ORCID, SAI
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Koňařík, M. (CZ)
Pirk, J. (CZ)
Bačáková, Lucie (FGU-C) RID, ORCIDSource Title CORONARY ARTERY DISEASE 2015. - Bologna : Medimond, 2016 - ISBN 978-88-7587-729-3 Pages s. 13-16 Number of pages 4 s. Publication form Print - P Action International Congress on Coronary Artery Disease /11./ Event date 29.11.2015 - 02.12.2015 VEvent location Florence Country IT - Italy Event type WRD Language eng - English Country IT - Italy Keywords decellularization ; stem cells ; pericardium Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects GAP108/12/1168 GA ČR - Czech Science Foundation (CSF) TA04011345 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NV15-29153A GA MZd - Ministry of Health (MZ) Institutional support FGU-C - RVO:67985823 UT WOS 000391237200003 Annotation Biological prostheses made of decellularized cross-linked bovine pericardium and porcine aortic heart valves or mechanical prostheses are used for transplantation of aortic heart valves. None of these prostheses contain autologous cells. The purpose of our study is to prepare decellularized porcine pericardium, which would be suitable for colonizing with both autologous stem cells and endothelial cells, and subsequently transplanted into a patient. For decellularization, we tested different solutions and time of exposure. Effectiveness of decellularization process was assessed by hematoxylin-eosin staining and Hoechst staining. Extracts of the decellularized pericardium were evaluated for biocompatibility using xCelligence method. Decellularized porcine pericardium seems to be a suitable scaffold for preparing bioartificial heart valves. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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