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Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity
- 1.0471527 - BC 2018 RIV GB eng J - Journal Article
Brož, Václav - Kučerová, Lucie - Rouhová, L. - Fleischmannová, Jana - Strnad, Hynek - Bryant, P. J. - Žurovec, Michal
Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity.
Scientific Reports. Roč. 7, FEB 23 (2017), č. článku 43273. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR GA14-27816S; GA ČR GA14-07172S
Institutional support: RVO:60077344 ; RVO:68378050
Keywords : Drosophila * innate immunity * IDGF2
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UMG-J)
Impact factor: 4.122, year: 2017
http://www.nature.com/articles/srep43273
Drosophila imaginal disc growth factors (IDGFs) are a family of chitinase-like glycoproteins abundantly secreted into the hemolymph by fat body and hemocytes.We show that the prototypical member, IDGF2, is an insulin-independent trophic and protective factor in cultured insect cells as well as in intact /Drosophila/ larvae and adults. It protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).Recombinant IDGF2 is able to renew the mitochondrial and cellular energy homeostasis and prevent the dissipation of mitochondrial membrane potential (delta-psi(m) in cultured cells. Transcriptional profiling supported the role of IDGF2 in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is induced by injury in larval stages. The highest IDGF2 accumulation found at garland and pericardial nephrocytes is also consistent with its role in organismal detoxification. Taken together, IDGF2 has similar overall homeostatic and protective effect as mammalian serum and chitinase-like glycoproteins recently associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas.
Permanent Link: http://hdl.handle.net/11104/0271169
Number of the records: 1