The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma

Lunov, Oleg; Zablotskyy, Vitaliy A.; Churpita, Olexandr; Jäger, Aleš; Polívka, Leoš; Syková, E.; Dejneka, Alexandr; Kubinová, Šárka

doi:https://dx.doi.org/10.1016/j.biomaterials.2015.12.027

Number of the records: 1

The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma

1.

SYSNO ASEP	0470525
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma
Author(s)	Lunov, Oleg (FZU-D)_ORCID Zablotskyy, Vitaliy A. (FZU-D)_RID Churpita, Olexandr (FZU-D)_{RID, ORCID} Jäger, Aleš (FZU-D)_{RID, ORCID} Polívka, Leoš (FZU-D) Syková, E. (CZ) Dejneka, Alexandr (FZU-D)_{RID, ORCID} Kubinová, Šárka (FZU-D)_{RID, ORCID}
Number of authors	8
Source Title	Biomaterials. - : Elsevier - ISSN 0142-9612 Roč. 82, Mar (2016), s. 71-83
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	non-thermal plasma ; bacteria ; cytotoxicity ; apoptosis ; bacterial inactivation ; reactive oxygen species (ROS)
Subject RIV	BO - Biophysics
R&D Projects	LO1409 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	Fellowship J. E. Purkyně GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LM2011026 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FZU-D - RVO:68378271
UT WOS	000370103900006
EID SCOPUS	84957564601
DOI	10.1016/j.biomaterials.2015.12.027
Annotation	Direct interactions of plasma matter with living cells and tissues can dramatically affect their functionality, initiating many important effects from cancer elimination to bacteria deactivation. However, the physical mechanisms and biochemical pathways underlying the effects of non-thermal plasma on bacteria and cell fate have still not been fully explored. Here, we report on the molecular mechanisms of non-thermal plasma-induced bacteria inactivation in both Gram-positive and Gram-negative strains. We demonstrate that depending on the exposure time plasma induces either direct physical destruction of bacteria or triggers programmed cell death (PCD) that exhibits characteristic features of apoptosis. The interplay between physical disruption and PCD is on the one hand driven by physical plasma parameters, and on the other hand by biological and physical properties of bacteria.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2017

Number of the records: 1