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POLYPEPTIDE ANTAGONISTS OF HUMAN IL-23 RECEPTOR FOR TREATMENT OF AUTOIMMUNE DISEASES

SYSNO ASEP	0470240
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	POLYPEPTIDE ANTAGONISTS OF HUMAN IL-23 RECEPTOR FOR TREATMENT OF AUTOIMMUNE DISEASES
Author(s)	Malý, Petr (BTO-N)_{RID, ORCID} Šebo, Peter (BTO-N) Kuchař, Milan (BTO-N)_RID Vaňková, Lucie (BTO-N) Petroková, Hana (BTO-N)_RID Osička, Radim (MBU-M)_{RID, ORCID}
Year of issue	2017
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	EP2922560
Date of the patent acceptance	04.01.2017
Name of the patent owner	Biotechnologický ústav AV ČR, v. v. i.
Code of the issuer name	EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/
Current use	A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
Language	eng - English
Keywords	psoriasis ; IL - 23 ; binding protein
Subject RIV	EB - Genetics ; Molecular Biology
Subject RIV - cooperation	Institute of Microbiology - Microbiology, Virology
Institutional support	BTO-N - RVO:86652036 ; MBU-M - RVO:61388971
Annotation	The present invention provides a novel class of polypeptides (REX binders), derived from an albumin-binding domain of the streptococcal protein G that inhibit binding of human IL-23 cytokine to its cognate IL-23 receptor. Blocking of interaction between p19/IL-23 subunit with the receptor leads to the suppresion of IL-23-dependent pro-inflammatory signaling pathway, resulting in an inhibitory effect on IL-23-stimulated Th-17 cell expansion. The invention further provides a DNA sequence encoding for such polypeptides and host cells containing such sequence. The polypeptides of the invention are useful as therapeutics and diagnostics.˙
Workplace	Institute of Biotechnology
Contact	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Year of Publishing	2017
Electronic address	https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=cz_CZ&FT=D&date=20150930&CC=EP&NR=2922560A1&KC=A1#

Number of the records: 1