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Silymarin from Silybum marianum – new approaches to separation and derivatization
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SYSNO ASEP 0468439 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Silymarin from Silybum marianum – new approaches to separation and derivatization Author(s) Biedermann, David (MBU-M) RID, ORCID
Křenková, Alena (MBU-M) RID
Valentová, Kateřina (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCIDSource Title Planta medica - ISSN 0032-0943
Roč. 81, S01/2016 (2016)Action Joint Natural Products Conference 2016 Event date 24.07.2016 - 27.07.2016 VEvent location Kodaň Country DK - Denmark Language eng - English Country DE - Germany Keywords Milk thistle ; silymarin ; silybin Subject RIV CC - Organic Chemistry R&D Projects GA15-03037S GA ČR - Czech Science Foundation (CSF) LD15081 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 Annotation Milk thistle (Silybum marianum) has been used medicinally from the 14th century [1]. Today it is a source of silymarin – extract of its fruits – which is used as nutraceutical and in the treatment of the liver problems. Despite high commercial value and large amount produced, until recently preparative separation of the silymarin component has not been achieved. Consequently, extensive research of its biological activity was not possible.
Silymarin was separated by the combination of Sephadex LH-20 chromatography, kinetic resolution and crystallization [2,3]. Silymarin flavonolignans were all obtained in gram quantities and high purity. The derivatization was mainly carried out on silychristin.[4] The toxicity was assayed against several cell lines of different histological origin, the cytotoxicity is mostly negligible. Radical scavenging activity and lipoperoxidation inhibition is very high (eg. anhydrosilychristin lipoperoxidation inhibition IC50=4.12 µM). This is in agreement with observed low redox potentials (dehydrosilychristin 0.39 V) [4].
Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2017
Number of the records: 1