Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine

0467726 - BC 2017 RIV GB eng J - Journal Article
Langhansová, Helena - Bopp, T. - Schmitt, E. - Kopecký, Jan
Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine.
Parasite immunology. Roč. 37, č. 2 (2015), s. 92-96. ISSN 0141-9838. E-ISSN 1365-3024
R&D Projects: GA ČR GCP302/11/J029
Institutional support: RVO:60077344
Keywords : chemokine * histamine * Ixodes ricinus * mcp-1 * Th2 response * tick saliva
Subject RIV: EC - Immunology
Impact factor: 1.917, year: 2015

The effect of Ixodes ricinus tick saliva on the production of various cytokines and chemokines by mouse splenocytes was tested by a cytokine array. We demonstrated a strong upregulation of three chemokines, monocyte chemoattractant protein-1 (MCP-1), thymus-derived chemotactic agent 3 (TCA-3) and macrophage inflammatory protein 2 (MIP-2). MCP-1 could be induced by tick saliva itself. While TCA-3 and MIP-2 are engaged in Th2 polarization of the host immune response associated with tick feeding, MCP-1 may act as a histamine release factor, increasing blood flow into the feeding lesion thus facilitating tick engorgement in the late, rapid feeding phase.
Permanent Link: http://hdl.handle.net/11104/0265767