Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

0466410 - ÚPT 2017 RIV DE eng C - Conference Paper (international conference)
Jiřík, Radovan - Taxt, T. - Souček, K. - Kratochvíla, Jiří - Macíček, Ondřej - Dražanová, Eva - Starčuk jr., Zenon
Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI.
Magma. Vol. 29 S1. Berlin: Springer, 2016, s. 447-448. E-ISSN 1352-8661.
[ESMRMB 2016 Congress. Vienna (AT), 29.09.2016-01.10.2016]
R&D Projects: GA ČR(CZ) GA16-13830S; GA MŠMT(CZ) LO1212
Institutional support: RVO:68081731
Keywords : DCE-MRI * AIF * high- and low-molecular weight
Subject RIV: BM - Solid Matter Physics ; Magnetism
http://link.springer.com/journal/10334/29/1/suppl/page/1

In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability- surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is
better. Simulation-based and blind deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.
Permanent Link: http://hdl.handle.net/11104/0264751