Current Topics in the Asymmetric Transfer Hydrogenation of Imines

0464131 - MBÚ 2017 RIV CZ eng J - Journal Article
Januščák, J. - Václavík, Jiří - Šot, P. - Pecháček, J. - Vilhanová, B. - Kuzma, Marek - Kačer, P.
Current Topics in the Asymmetric Transfer Hydrogenation of Imines.
Chemické listy. Roč. 109, č. 7 (2015), s. 492-498. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA ČR GAP106/12/1276; GA MŠMT(CZ) LO1509
Institutional support: RVO:61388971
Keywords : asymmetric transfer hydrogenation * ruthenium * isoquinoline
Subject RIV: EE - Microbiology, Virology
Impact factor: 0.279, year: 2015

At present, asymmetric hydrogenation is an attractive method for the synthesis of enantioenriched chiral compounds, such as drugs, agrochemicals or fragrances. This review is focused on the asymmetric transfer hydrogenation (ATH) of imines, in particular 3,4-dihydro-isoquinolines. Mechanistic aspects of ATH are discussed and analytical methods for the monitoring of ATH as developed in our group are presented. The effect of structural changes of the catalyst and substrate on the course of ATH is also described. The influence of temperature, reactant concentrations and other reaction parameters as well as the utilizability of ATH in chemical industry are discussed.
Permanent Link: http://hdl.handle.net/11104/0263343