From simple to supercomplex: mitochondrial genomes of euglenozoan protists

0461890 - BC 2017 RIV GB eng J - Journal Article
Faktorová, Drahomíra - Dobáková, Eva - Peña-Diaz, Priscila - Lukeš, Julius
From simple to supercomplex: mitochondrial genomes of euglenozoan protists.
F1000Research. Roč. 5, 15 NOV (2016), č. článku 392. ISSN 2046-1402
R&D Projects: GA ČR GA15-21974S
Institutional support: RVO:60077344
Keywords : euglenozoa * mitochondria * mitochondrial genome
Subject RIV: EB - Genetics ; Molecular Biology

Mitochondria are double membrane organelles of endosymbiotic origin, best known for constituting the centre of energetics of a eukaryotic cell. They contain their own mitochondrial genome, which as a consequence of gradual reduction during evolution typically contains less than two dozens of genes. In this review, we highlight the extremely diverse architecture of mitochondrial genomes and mechanisms of gene expression between the three sister groups constituting the phylum Euglenozoa - Euglenida, Diplonemea and Kinetoplastea. The earliest diverging euglenids possess a simplified mitochondrial genome and a conventional gene expression, whereas both are highly complex in the two other groups. The expression of their mitochondrial-encoded proteins requires extensive post-transcriptional modifications guided by complex protein machineries and multiple small RNA molecules. Moreover, the least studied diplonemids, which have been recently discovered as a highly abundant component of the world ocean plankton, possess one of the most complicated mitochondrial genome organisations known to date.
Permanent Link: http://hdl.handle.net/11104/0267774