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Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence
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SYSNO ASEP 0461446 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence Author(s) Mordukhovich, I. (US)
Beyea, J. (US)
Herring, A. H. (US)
Hatch, M. (US)
Stellman, S. D. (US)
Teitelbaum, S. L. (US)
Richardson, D.B. (US)
Millikan, R. C. (US)
Engel, L.S. (US)
Shantakumar, S. (US)
Steck, S.E. (US)
Neugut, A. I. (US)
Rössner ml., Pavel (UEM-P) RID, ORCID
Santella, R. M. (US)
Gammon, M. D. (US)Source Title International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 139, č. 2 (2016), s. 310-321Number of pages 12 s. Language eng - English Country DE - Germany Keywords traffic ; DNA repair ; polycyclic aromatic hydrocarbons ; breast cancer Subject RIV DN - Health Impact of the Environment Quality Institutional support UEM-P - RVO:68378041 UT WOS 000378417500007 EID SCOPUS 84963799708 DOI 10.1002/ijc.30079 Annotation Vehicular traffic polycyclic aromatic hydrocarbons (PAHs) have been associated with breast cancer incidence in epidemiologic studies, including our own. Because PAHs damage DNA by forming adducts and oxidative lesions, genetic polymorphisms that alter DNA repair capacity may modify associations between PAH-related exposures and breast cancer risk. Our goal was to examine the association between vehicular traffic exposure and breast cancer incidence within strata of a panel of nine biologically plausible nucleotide excision repair (NER) and base excision repair (BER) genotypes. Residential histories of 1,508 cases and 1,556 controls were assessed in the Long Island Breast Cancer Study Project between 1996 and 1997 and used to reconstruct residential traffic exposures to benzo[a]pyrene, as a proxy for traffic-related PAHs. Likelihood ratio tests from adjusted unconditional logistic regression models were used to assess multiplicative interactions. A gene-traffic interaction was evident (p = 0.04) for ERCC2 (Lys751); when comparing the upper and lower tertiles of 1995 traffic exposure estimates, the odds ratio (95% confidence interval) was 2.09 (1.13, 3.90) among women with homozygous variant alleles. Corresponding odds ratios for 1960-1990 traffic were also elevated nearly 2-3-fold for XRCC/(Arg194Trp), XRCC1(Arg399Gln) and OGG1(-Ser326Cys), but formal multiplicative interaction was not evident. When DNA repair variants for ERCC2, XRCC1 and OGG1 were combined, among women with 4-6 variants, the odds ratios were 2.32 (1.22, 4.49) for 1995 traffic and 2.96 (1.06, 8.21) for 1960-1990 traffic. Our study is first to report positive associations between traffic-related PAH exposure and breast cancer incidence among women with select biologically plausible DNA repair genotypes. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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