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Water soluble poly(styrene sulfonate)-b-poly(vinylidene fluoride)-b-poly(styrene sulfonate) triblock copolymer nanoparticles
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SYSNO ASEP 0460137 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Water soluble poly(styrene sulfonate)-b-poly(vinylidene fluoride)-b-poly(styrene sulfonate) triblock copolymer nanoparticles Author(s) Černoch, Peter (UMCH-V) RID, ORCID
Černochová, Zulfiya (UMCH-V) RID, ORCID
Petrova, Svetlana (UMCH-V) RID, ORCID
Kaňková, Dana (UMCH-V)
Kim, J.-S. (US)
Vasu, V. (US)
Asandei, A. D. (US)Source Title RSC Advances. - : Royal Society of Chemistry
Roč. 6, č. 60 (2016), s. 55374-55381Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords polystyrenesulfonate ; poly(neopentyl styrenesulfonate) ; PVDF Subject RIV CD - Macromolecular Chemistry R&D Projects LH14038 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000378274800089 EID SCOPUS 84974605050 DOI 10.1039/C6RA10241G Annotation A visible light, Mn-2(CO)(2)-photomediated process was used to enable the iodine degenerative transfer controlled radical polymerization of vinylidene fluoride (VDF) initiated from I-(CF2)(6)-I, and the successive quantitative activation of the similar to CH2-CF2-I and similar to CF2-CH2-I chain ends of I-PVDF-I, to produce a series of PNpSS-b-PVDF-b-PNpSS triblock copolymers (NpSS/VDF/NpSS = 4/60/4, 15/60/15, 34/60/34) with neopentyl styrene sulfonate (NpSS), which upon NaN3 deprotection, afforded the corresponding PNaSS-b-PVDF-b-PNaSS. All blocks, as well as PVDF, PNpSS and PNaSS formed water stable dispersion/solutions following either nanoprecipitation from acetone (PVDF, PNpSS, and PNpSS-b-PVDF-b-PNpSS) or direct dissolution in water (PNaSS, PNaSS-b-PVDF-b-PNaSS). Remarkably, all PNaSS-b-PVDF-b-PNaSS triblocks also provided indefinitely stable systems even under the high ionic strength conditions of phosphate buffered saline (PBS) solutions, corresponding to cell-isotonic, pH = 7.4 conditions. These trends were found to be consistent with the block composition dependence of the apparent hydrodynamic radius (R-h), conductivity, and zeta potential (zeta), where R-h increases upon deprotection from about 35-25 nm to about 168-136 nm in water, and decreases to 133-86 nm in PBS solutions, zeta decreases from similar to-40 mV to similar to-70 mV in water and increases to similar to-18 mV in PBS, and where the conductivity is negligible for PNpSS-b-PVDF-b-PNpSS but then increases linearly to similar to 0.2 mS cm(-1) for PNaSS-b-PVDF-b-PNaSS in water to reach similar to 17 mS cm(-1) in PBS. Finally, the blocks were evaluated as promising F-19-MRI contrast agents. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017
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