Number of the records: 1
Alkaline Phosphatase in Stem Cells
- 1.
SYSNO ASEP 0457648 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Alkaline Phosphatase in Stem Cells Author(s) Štefková, K. (CZ)
Procházková, Jiřina (BFU-R) RID, ORCID
Pachernik, J. (CZ)Number of authors 3 Source Title Stem Cells International - ISSN 1687-966X
Roč. 2015, č. 2015 (2015)Number of pages 12 s. Publication form Online - E Language eng - English Country US - United States Keywords PRIMORDIAL GERM-CELLS ; P38 MAP KINASE ; EMBRYONAL CARCINOMA-CELLS Subject RIV BO - Biophysics Institutional support BFU-R - RVO:68081707 UT WOS 000350163700001 DOI 10.1155/2015/628368 Annotation Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2016
Number of the records: 1