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Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice
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SYSNO ASEP 0457632 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice Author(s) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Dušek, L. (CZ)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCIDNumber of authors 5 Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, č. 2 (2015), s. 255-262Number of pages 8 s. Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords Adenosine A(3) receptor knock-out mice ; Hematopoiesis ; 5-fluorouracil-induced hematotoxicity Subject RIV BO - Biophysics Institutional support BFU-R - RVO:68081707 UT WOS 000357409400013 Annotation The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2016
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