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Fluorescence optical imaging in anticancer drug delivery
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SYSNO ASEP 0456934 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fluorescence optical imaging in anticancer drug delivery Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Lucas, H. (DE)
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Mueller, T. (DE)
Mäder, K. (DE)Source Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 226, 28 March (2016), s. 168-181Number of pages 14 s. Language eng - English Country NL - Netherlands Keywords fluorescence imaging ; drug delivery ; theranostics Subject RIV CD - Macromolecular Chemistry R&D Projects GA15-02986S GA ČR - Czech Science Foundation (CSF) LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000372155700016 EID SCOPUS 84959019806 DOI 10.1016/j.jconrel.2016.02.022 Annotation In the past several decades, nanosized drug delivery systems with various targeting functions and controlled drug release capabilities inside targeted tissues or cells have been intensively studied. Understanding their pharmacokinetic properties is crucial for the successful transition of this research into clinical practice. Among others, fluorescence imaging has become one of the most commonly used imaging tools in pre-clinical research. The development of increasing numbers of suitable fluorescent dyes excitable in the visible to near-infrared wavelengths of the spectrum has significantly expanded the applicability of fluorescence imaging. This paper focuses on the potential applications and limitations of non-invasive imaging techniques in the field of drug delivery, especially in anticancer therapy. Fluorescent imaging at both the cellular and systemic levels is discussed in detail. Additionally, we explore the possibility for simultaneous treatment and imaging using theranostics and combinations of different imaging techniques, e.g., fluorescence imaging with computed tomography. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017
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