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Biodegradation of endocrine-disrupting compounds by ligninolytic fungi: mechanisms involved in the degradation

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    SYSNO ASEP0456529
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleBiodegradation of endocrine-disrupting compounds by ligninolytic fungi: mechanisms involved in the degradation
    Author(s) Cajthaml, Tomáš (MBU-M) RID, ORCID
    Source TitleEnvironmental Microbiology. - : Wiley - ISSN 1462-2912
    Roč. 17, č. 12 (2015), s. 4822-4834
    Number of pages13 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsWHITE-ROT FUNGUS ; PHANEROCHAETE-SORDIDA YK-624 ; POLYCYCLIC AROMATIC-HYDROCARBONS
    Subject RIVEE - Microbiology, Virology
    R&D ProjectsTE01020218 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
    GA13-28283S GA ČR - Czech Science Foundation (CSF)
    Institutional supportMBU-M - RVO:61388971
    UT WOS000368457800002
    DOI10.1111/1462-2920.12460
    AnnotationWithout any doubt, endocrine-disrupting compounds (EDCs) represent an environmental risk for wildlife and human beings. Endocrine-disrupting effects were found for many chemicals in products for personal use, industrial compounds and even in classical persistent organic pollutants (POPs). In order to understand the fate of EDCs in the environment, it is highly important to identify and to clarify the biodegradation mechanisms that can lead to their decomposition. Ligninolytic fungi (LF) are interesting microorganisms that are capable of participating in a variety of versatile decomposition mechanisms. The microorganisms represent a useful model group and, moreover, LF or their enzymes can be actively used for decontamination. Potential optimization of the decontamination process provides another important reason why it is necessary for understanding the mechanisms of EDC transformation. This minireview summarizes current knowledge about the LF biodegradation mechanisms of the most important micropollutants (xenoestrogens), including nonylphenols, bisphenol A and 17 alpha-ethinylestradiol and polychlorinated biphenyls as POPs with endocrine-disrupting potency. Generally, LF exhibit the ability to either polymerize the target pollutants or to substantially decompose the original structure using ligninolytic enzymes and cytochrome P-450. Moreover, most of the transformation processes are accompanied by reduction of the endocrine-disrupting activity or ecotoxicity.
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2016
Number of the records: 1  

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