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Targeted modulation of alternative splicing by TALE-directed chromatin editing
- 1.0454301 - ÚMG 2016 RIV GB eng A - Abstract
Bieberstein, Nicole - Staněk, David
Targeted modulation of alternative splicing by TALE-directed chromatin editing.
FEBS Journal. Roč. 282, SI (2015), s. 210-210. ISSN 1742-464X. E-ISSN 1742-4658.
[40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life. 04.07.2015-09.07.2015, Berlín]
R&D Projects: GA ČR(CZ) GBP305/12/G034
Institutional support: RVO:68378050
Keywords : histone methylation * pre-mRNA splicing * TALEN
Subject RIV: EB - Genetics ; Molecular Biology
To reveal how local chromatin modulates the splicing outcome we developed a new method based on Transcription Activator-Like Effector Nuclease (TALEN) technology. We replaced the nuclease domain with chromatin modifying domain and tested how TALE based targeting of histone methyltransferases and a demethylase influences splicing of the targeted exon.
Permanent Link: http://hdl.handle.net/11104/0255078
Number of the records: 1