Number of the records: 1  

Gene expression profiling of changes induced by maternal diabetes in the embryonic heart

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    SYSNO ASEP0453296
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleGene expression profiling of changes induced by maternal diabetes in the embryonic heart
    Author(s) Bohuslavová, Romana (BTO-N) RID
    Škvorová, Lada (BTO-N)
    Čerychová, Radka (BTO-N)
    Pavlínková, Gabriela (BTO-N) RID, ORCID
    Source TitleReproductive Toxicology. - : Elsevier - ISSN 0890-6238
    Roč. 57, NOV 2015 (2015), s. 147-156
    Number of pages10 s.
    Languageeng - English
    CountryUS - United States
    KeywordsDiabetic embryopathy ; Vascular endothelial growth factor A (VEGF-A) ; Gene expression ; Cardiovascular defects
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsGA301/09/0117 GA ČR - Czech Science Foundation (CSF)
    ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportBTO-N - RVO:86652036
    CEZAV0Z50520701 - BTO-N (2007-2013)
    UT WOS000360322300017
    DOI10.1016/j.reprotox.2015.06.045
    AnnotationCardiovascular defects are one of the most common congenital defects associated with maternal diabetes. Based on whole embryo gene expression microarray analysis, 11 genes were chosen for temporal expression analysis of diabetes-exposed hearts. The majority of the selected genes were deregulated in diabetes-exposed hearts compared to our controls at E13.5, E14.5, and E18.5. We showed increased hypoxia and HIF-1 alpha protein levels in diabetes-exposed hearts at E10.5, which is a critical time point for the induction of developmental defects associated with diabetic embryopathy. Additionally, we found increased cardiac Vegfa levels that might trigger developmental abnormalities associated with diabetic embryopathy. Our results show that maternal diabetes affects the temporal expression pattern of gene encoding molecules involved in heart development and tissue remodelling and that these molecules might affect heart maturation processes and thus, the final outcome of diabetic pregnancies. (C) 2015 Elsevier Inc. All rights reserved.
    WorkplaceInstitute of Biotechnology
    ContactMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Year of Publishing2016
Number of the records: 1  

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