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Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study
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SYSNO ASEP 0453143 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study Author(s) Pásek, Michal (UT-L) RID, ORCID
Bébarová, M. (CZ)
Christé, G. (FR)
Šimurdová, M. (CZ)
Šimurda, J. (CZ)Source Title Medical & Biological Engineering & Computing. - : Springer - ISSN 0140-0118
Roč. 54, č. 5 (2016), s. 753-762Number of pages 10 s. Publication form Print - P Language eng - English Country DE - Germany Keywords ethanol ; cardiomyocyte ; action potential ; rat ventricular cell model ; human ventricular cell model Subject RIV BO - Biophysics Institutional support UT-L - RVO:61388998 UT WOS 000374470600005 EID SCOPUS 84939446301 DOI https://doi.org/10.1007/s11517-015-1366-8 Annotation Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca2+ dynamics seem to be altered as well. In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocytes to assess the share of ionic current components in ethanol-induced changes in AP configuration and cytosolic Ca2+ transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes in AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at ≥8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of IK1. The cytosolic Ca2+ transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of ICa. In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on IKr, the key repolarising current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2017
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