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Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision
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SYSNO ASEP 0449363 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision Author(s) Uchytilová, Eva (FGU-C)
Špicarová, Diana (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCIDSource Title European Journal of Pain. - : Elsevier - ISSN 1090-3801
Roč. 19, č. 10 (2015), s. 1496-1505Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords pain ; spinothalamic ; capsaicin ; TRPV1 ; PSDC Subject RIV FH - Neurology R&D Projects GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) LH12058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GPP303/12/P510 GA ČR - Czech Science Foundation (CSF) EE2.3.30.0025 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000362691400012 EID SCOPUS 84943637943 DOI 10.1002/ejp.683 Annotation There was a robust increase in c-Fos immunopositivity in the STT and PSDC neurons, in the control animals after a plantar incision. This increase in c-Fos expression was significantly attenuated in animals in which a single high-concentration capsaicin injection was made intradermally at the incision site 24 h before the surgery. Our results suggest that activation of both STT and PSDC neurons is involved in development of pain states present after surgical incision and that TRPV1-containing peripheral nerve fibres are needed for c-Fos expression in these dorsal horn neurons after plantar incision Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
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