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Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer
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SYSNO ASEP 0447207 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer Author(s) Berridge, M.V. (NZ)
Dong, L.-F. (AU)
Neužil, Jiří (BTO-N) RIDSource Title Cancer Research. - : American Association for Cancer Research - ISSN 0008-5472
Roč. 75, č. 16 (2015), s. 3203-3208Number of pages 6 s. Language eng - English Country US - United States Keywords MESENCHYMAL STEM-CELLS ; TUNNELING NANOTUBES ; CANCER-CELLS Subject RIV EB - Genetics ; Molecular Biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA15-02203S GA ČR - Czech Science Foundation (CSF) Institutional support BTO-N - RVO:86652036 UT WOS 000359562100002 DOI 10.1158/0008-5472.CAN-15-0859 Annotation Mitochondrial DNA (mtDNA), encoding 13 out of more than 1,000 proteins of the mitochondrial proteome, is of paramount importance for the bioenergetic machinery of oxidative phosphorylation that is required for tumor initiation, propagation, and metastasis. In stark contrast to the widely held view that mitochondria and mtDNA are retained and propagated within somatic cells of higher organisms, recent in vitro and in vivo evidence demonstrates that mitochondria move between mammalian cells. This is particularly evident in cancer where defective mitochondrial respiration can be restored and tumor-forming ability regained by mitochondrial acquisition. This paradigm shift in cancer cell biology and mitochondrial genetics, concerning mitochondrial movement between cells to meet bioenergetic needs, not only adds another layer of plasticity to the armory of cancer cells to correct damaged mitochondria, but also points to potentially new therapeutic approaches. (C) 2015 AACR. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2016
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