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Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein
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SYSNO ASEP 0446300 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein Author(s) Šilhavý, Jan (FGU-C) RID, ORCID
Zídek, Václav (FGU-C) RID
Landa, Vladimír (FGU-C) RID
Šimáková, Miroslava (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Oliyarnyk, O. (CZ)
Malínská, H. (CZ)
Kazdová, L. (CZ)
Mancini, M. (IT)
Pravenec, Michal (FGU-C) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, č. 3 (2015), s. 295-301Number of pages 7 s. Language eng - English Country CZ - Czech Republic Keywords rosuvastatin ; kidney damage ; CRP ; transgenic ; spontaneously hypertensive rat Subject RIV EB - Genetics ; Molecular Biology R&D Projects LH11049 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LL1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NT14325 GA MZd - Ministry of Health (MZ) GB14-36804G GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000357411100002 EID SCOPUS 84934288264 Annotation Recently, we derived “humanized” spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress, several features of metabolic syndrome and target organ injury. In the current study, we tested the effects of rosuvastatin on kidney injury in SHR-CRP males versus untreated SHR-CRP and SHR controls. In SHR-CRP transgenic rats, treatment with rosuvastatin, compared to untreated transgenic rats and SHR controls, was associated with significantly reduced systemic inflammation which was accompanied with activation of antioxidative enzymes in the kidney and with amelioration of histopathological changes in the kidney. These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
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