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Rapid diagnosis of methanol poisoning by direct coupling of microextraction techniques to capillary zone electrophoresis
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SYSNO ASEP 0444986 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Rapid diagnosis of methanol poisoning by direct coupling of microextraction techniques to capillary zone electrophoresis Author(s) Pantůčková, Pavla (UIACH-O) RID
Kubáň, Pavel (UIACH-O) RID, ORCID
Boček, Petr (UIACH-O) RIDNumber of authors 3 Source Title Analytical Methods and Human Health. Conference Proceedings. - Bratislava : Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 2015 - ISBN 978-80-971179-5-5 Pages s. 252-253 Number of pages 2 s. Publication form Medium - C Action International Conference Analytical Methods and Human Health /20./ Event date 15.06.2015-18.06.2015 VEvent location Patince Country SK - Slovakia Event type EUR Language eng - English Country SK - Slovakia Keywords methanol poisoning ; microextraction techniques ; capillary electrophoresis Subject RIV CB - Analytical Chemistry, Separation R&D Projects GA13-05762S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 Annotation A massive methanol poisoning reported in 2012 in the Czech Republic pointed out the need for development of a robust analytical method suitable for rapid methanol poisoning diagnosis. Formate is the major metabolite in methanol poisoning and is primarily responsible for its toxicity. Formate can also serve as a reliable marker of methanol poisoning since formate concentrations in blood can rise to 10-30 mM in case of acute methanol poisoning, which are almost two orders of magnitude higher than the reference range (0-0.4 mM) reported for blood formate in healthy individuals [1,2]. Several approaches based on capillary zone electrophoresis (CZE) have been reported for formate determination in blood samples and for methanol poisoning diagnosis recently [3-6]. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2016
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