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DNA and RNA Quadruplex-Binding Proteins
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SYSNO ASEP 0442425 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Článek ve WOS Title DNA and RNA Quadruplex-Binding Proteins Author(s) Brázda, Václav (BFU-R) RID, ORCID
Haroniková, Lucia (BFU-R)
Liao, J.C.C. (AU)
Fojta, Miroslav (BFU-R) RID, ORCIDNumber of authors 4 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 15, č. 10 (2014), s. 17493-17517Number of pages 25 s. Publication form Print - P Language eng - English Country CH - Switzerland Keywords DNA quadruplex ; RNA quadruplex ; telomere Subject RIV BO - Biophysics R&D Projects GBP206/12/G151 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000348039400008 DOI 10.3390/ijms151017493 Annotation Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)(n), is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes. The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins. A number of G-rich sequences are also present in promoter region of estrogen receptor alpha. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
Number of the records: 1