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Zeolites Promoting Quinoline Synthesis via Friedlander Reaction
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SYSNO ASEP 0437032 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Zeolites Promoting Quinoline Synthesis via Friedlander Reaction Author(s) López-Sanz, J. (ES)
Pérez-Mayoral, E. (ES)
Vitvarová, Dana (UFCH-W) RID
Martín-Aranda, R. M. (ES)
López-Peinado, A. J. (ES)Source Title Topics in Catalysis. - : Springer - ISSN 1022-5528
Roč. 53, 19-20 (2010), s. 1430-1437Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords heterogeneous catalysis ; zeolites ; quinolines Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GD203/08/H032 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000283584800019 EID SCOPUS 78650236897 DOI 10.1007/s11244-010-9603-8 Annotation Catalytic performance of zeolites H-BEA, H-MFI, H-FAU and H-MOR, exhibiting textural differences and with different Bronsted and Lewis acid sites concentration, have been studied in the synthesis of quinolines via Friedlander reaction. H-BEA and H-FAU efficiently promoted the condensation of 2-aminoaryl ketones 3 with ethyl acetoacetate (4a) or acetylacetone (4b) under mild reaction conditions, those being the first examples of zeolites as catalysts for this transformation. While H-FAU showed similar catalytic behaviour than that reported for (Al)SBA-15 affording mixtures of quinolines 5 and quinolones 6, H-BEA mainly led to quinolines 5 in almost total selectivity and good yields. However, H-MFI and H-MOR zeolites afforded quinolones 6 as the major reaction product. Methodology reported here was found to be useful for the synthesis of biologically active compounds with excellent yields avoiding unnecessary purifications protocols and tedious work-up procedures. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2015
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