Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations

0436869 - FZÚ 2015 RIV GB eng J - Journal Article
Lunov, Oleg - Zablotskyy, Vitaliy A. - Churpita, Olexandr - Chánová, Eliška - Syková, Eva - Dejneka, Alexandr - Kubinová, Šárka
Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations.
Scientific Reports. Roč. 4, NOV (2014), "7129-1"-"7129-11". ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT LO1309
Grant - others:AV ČR(CZ) M100101219
Institutional support: RVO:68378271 ; RVO:61389013 ; RVO:68378041
Keywords : cell death * non-thermal plasma * therapeutic perspectives
Subject RIV: BO - Biophysics; FH - Neurology (UEM-P); CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 5.578, year: 2014

Non-thermal plasma has been recognized as a promising tool across a vast variety of biomedical applications, with the potential of creating novel therapeutic methods. However, the understanding of the molecular mechanisms behind non-thermal plasma cellular effects remains a significant challenge. In this study, we show how two types of different non-thermal plasmas induce cell death in mammalian cell cultures via the formation of multiple intracellular reactive oxygen/nitrogen species. Our results showed a discrepancy in the superoxide accumulation and lysosomal activity in response to air and helium plasma,suggesting that triggered signalling cascades might be grossly different between different plasmas. Inaddition, the effects of ozone, a considerable component of non-thermal plasma, have been simultaneously evaluated and have revealed much faster and higher cytotoxic effects.
Permanent Link: http://hdl.handle.net/11104/0240503