Neurology Laboratory and Clinical Research Series

0436771 - ÚEM 2015 US eng M - Monography Chapter
Hejčl, Aleš - Jendelová, Pavla - Syková, Eva
Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair.
Neurology Laboratory and Clinical Research Series. New York: NOVA SCIENCE PUBLISHERS, 2010 - (Bekovsky T. C.), s. 297-320. ISBN 978-1-60876-002-2
Institutional support: RVO:68378041
Keywords : spinal cord injury * hydrogel * tissue engineering
Subject RIV: FH - Neurology

Both therapeutic modalities, i.e. MSCs and hydrogels, can be applied together to combine the advantages of both therapeutic approaches. Hydrogels were used as 3D carriers for stem cells and implanted into acute spinal cord lesions. Various hydrogels are suitable as carriers of MSCs and/or other stem cells, as the cells survived in the hydrogels for several months. Further, these hydrogel constructs (hydrogel+MSCs) were also tested in an animal model of chronic SCI. The hydrogel constructs seeded with MSCs created a successful bridge, preventing tissue atrophy and improving functional outcome.
Permanent Link: http://hdl.handle.net/11104/0240445