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Estrogenic activity in extracts and exudates of cyanobacteria and green algae
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SYSNO ASEP 0436173 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Estrogenic activity in extracts and exudates of cyanobacteria and green algae Author(s) Sychrová, E. (CZ)
Štěpánkdová, T. (CZ)
Nováková, K. (CZ)
Bláha, Luděk (BU-J)
Giesy, J.P. (US)
Hilscherová, K. (CZ)Number of authors 6 Source Title Environment International. - : Elsevier - ISSN 0160-4120
Roč. 39, č. 1 (2012), s. 134-140Number of pages 7 s. Language eng - English Country US - United States Keywords cyanobacteria ; endocrine disruption ; estrogenicity ; algae ; phytoplankton Subject RIV EF - Botanics R&D Projects GA524/08/0496 GA ČR - Czech Science Foundation (CSF) Institutional support BU-J - RVO:67985939 UT WOS 000300129100018 DOI 10.1016/j.envint.2011.10.004 Annotation Here is presented some of the first information on interactions of compounds produced by cyanobacteria and green algae with estrogen receptor signaling. Estrogenic potency of aqueous extracts and exudates (culture spent media with extracellular products) of seven species of cyanobacteria (10 different laboratory strains) and two algal species were assessed by use of in vitro trans-activation assays. Compounds produced by cyanobacteria and algae, and in particular those excreted from the cells, were estrogenic. Most exudates were estrogenic with potencies expressed at 50% of the maximum response under control of the estrogen receptor ranging from 0.2 to 7.2 ng 17 beta-estradiol (E-2) equivalents (EEQ)/L The greatest estrogenic potency was observed for exudates of Microcystis aerigunosa, a common species that forms water blooms. Aqueous extracts of both green algae, but only one species of cyanobacteria (Aphanizomenon gracile) elicited significant estrogenicity with EEQ ranging from 15 to 280 ng 17 beta-estradiol (E-2)/g dry weight. Scenedesmus quadricauda exudates and extracts of Aphanizomenon flos-aquae were antagonistic to the ER when coexposed to E2. The EEQ potency was not correlated with concentrations of cyanotoxins, such as microcystin and cylindrospermopsin, which suggests that the EEQ was comprised of other compounds. The study demonstrates some differences between the estrogenic potency of aqueous extracts prepared from the same species, but of different origin, while the effects of exudates were comparable within species. The observed estrogenic potencies are important namely in relation to the possible mass expansion of cyanobacteria and release of the active compounds into surrounding water. Workplace Institute of Botany Contact Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8 Year of Publishing 2015
Number of the records: 1