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Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance
- 1.0436080 - ÚEM 2015 RIV US eng J - Journal Article
Jurášek, M. - Rimpelová, S. - Kmoníčková, Eva - Drašar, P. - Ruml, T.
Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance.
Journal of Medicinal Chemistry. Roč. 57, č. 19 (2014), s. 7947-7954. ISSN 0022-2623. E-ISSN 1520-4804
Grant - others:GA ČR(CZ) GA14-28334S; GA MŠMT(CZ) 20/2014
Program: GA
Institutional support: RVO:68378041
Keywords : trilobolide * nitric oxide * endoplasmic reticulum
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 5.447, year: 2014
Anotace v a.j.: Trilobolide (Tb) is a potent natural counterpart of thapsigargin. The live-cell imaging of the prepared bioconjugates brought clear evidence that Tb–Bodipy localized in the endoplasmic reticulum (ER) of various cancer cell lines. Cytotoxicity of Tb conjugates and impact on the mitochondrial physiology and nitric oxide release and cytokine secretion were also studied.
Permanent Link: http://hdl.handle.net/11104/0239877
Number of the records: 1