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Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids
- 1.0435667 - FGÚ 2015 RIV US eng J - Journal Article
Villarroya, J. - Flachs, Pavel - Redondo-Angulo, I. - Giralt, M. - Medříková, Daša - Villarroya, F. - Kopecký, Jan - Planavila, A.
Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids.
Lipids. Roč. 49, č. 11 (2014), s. 1081-1089. ISSN 0024-4201. E-ISSN 1558-9307
R&D Projects: GA ČR(CZ) GA13-00871S
Institutional support: RVO:67985823
Keywords : fibroblast growth factor-21 * long-chain n-3 polyunsaturated fatty acids
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 1.854, year: 2014
We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-α target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders
Permanent Link: http://hdl.handle.net/11104/0239622
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