Number of the records: 1
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats
- 1.
SYSNO ASEP 0433963 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats Author(s) Špolcová, Andrea (UOCHB-X) RID, ORCID
Mikulášková, Barbora (UOCHB-X)
Kršková, K. (SK)
Gajdošechová, L. (SK)
Zórad, Š. (SK)
Olszanecki, R. (PL)
Suski, M. (PL)
Bujak-Gizycka, B. (PL)
Železná, Blanka (UOCHB-X) RID, ORCID
Maletínská, Lenka (UOCHB-X) RID, ORCIDNumber of authors 10 Source Title BMC Neuroscience. - : BioMed Central - ISSN 1471-2202
Roč. 15, Sep 25 (2014), 111/1-111/8Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords Zucker fa/fa rats ; insulin resistance ; obesity ; GSK-3 beta ; Tau protein Subject RIV CE - Biochemistry R&D Projects GAP303/12/0576 GA ČR - Czech Science Foundation (CSF) 7AMB12FR011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 UT WOS 000342367600001 EID SCOPUS 84908131278 DOI https://doi.org/10.1186/1471-2202-15-111 Annotation Background: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results: Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3 beta (glycogen synthase kinase 3 beta) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions: Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather than hyperglycemia, appears to promote central insulin resistance and the Tau pathology in fa/fa rats. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2015
Number of the records: 1