Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors

Šolínová, Veronika; Kaiser, Martin Maxmilian; Lukáč, Miloš; Janeba, Zlatko; Kašička, Václav

Number of the records: 1

Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors

1.

SYSNO ASEP	0430071
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	The record was not marked in the RIV
Title	Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors
Author(s)	Šolínová, Veronika (UOCHB-X)_{RID, ORCID} Kaiser, Martin Maxmilian (UOCHB-X)_{RID, ORCID} Lukáč, Miloš (UOCHB-X) Janeba, Zlatko (UOCHB-X)_{RID, ORCID} Kašička, Václav (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 51S. - Olomouc : Palacký University, 2014 / Maier V. ; Ševčík J. - ISSN 0232-0061 - ISBN 978-80-244-3950-1
Pages	s. 207-209
Number of pages	3 s.
Publication form	Print - P
Action	Advances in Chromatography and Electrophoresis & Chiranal 2014
Event date	10.02.2014-14.02.2014
VEvent location	Olomouc
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	CZ - Czech Republic
Keywords	acyclic nucleoside phosphonates ; capillary electrophoresis ; enantiopurity analysis
Subject RIV	CB - Analytical Chemistry, Separation
R&D Projects	GAP206/12/0453 GA ČR - Czech Science Foundation (CSF)
	GA13-17224S GA ČR - Czech Science Foundation (CSF)
	VG20102015046 GA MV - Ministry of Interior (MV)
Institutional support	UOCHB-X - RVO:61388963
Annotation	Capillary electrophoresis with neutral and cationic cyclodextrins as chiral selectors was applied for determination of enantiopurity analysis of new types of six acyclic nucleoside phosphonates, nucleotide analogues bearing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid, 2-((diisopropoxyphosphonyl)methoxy)propanoic acid or 2 (phosphonomethoxy)propanoic acid moieties attached to adenine, guanine, 2,6-diaminopurine, uracil and 5-bromouracil nucleobases. All these compounds were found to be synthesized in pure enantiomeric forms. Employing the UV-absorption detection at 206 nm, their detection limits were in the low micromolar level.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2015

Number of the records: 1