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Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ
- 1.0425635 - MBÚ 2014 RIV DE eng J - Journal Article
Najmanová, Lucie - Kutejová, Eva - Kadlec, J. - Polan, M. - Olšovská, Jana - Benada, Oldřich - Novotná, Jitka - Kameník, Zdeněk - Halada, Petr - Bauer, J. - Janata, Jiří
Characterization of N-Demethyl lincosamide Methyltransferases LmbJ and CcbJ.
Chembiochem. Roč. 14, č. 17 (2013), s. 2259-2262. ISSN 1439-4227. E-ISSN 1439-7633
R&D Projects: GA MŠMT(CZ) EE2.3.20.0055; GA MŠMT(CZ) EE2.3.30.0003
Institutional support: RVO:61388971
Keywords : antibiotics * lincomycin * natural products
Subject RIV: CE - Biochemistry
Impact factor: 3.060, year: 2013
Two putative methyltrasferases LmbJ and CcbJ from the biosynthesis of lincosamide antibiotics lincomycin and celesticetin respectively, were characterized biochemicalla and confirmed do possess a homooligomeric, probably hexameric quaternary structure. LmbJ was confirmed to convert N-demethyl lincomycin. CcbJ is able to catalyze the same reaction with comparable efficiency, indicating tha its substrate specificity is somewhat relaxed.
Permanent Link: http://hdl.handle.net/11104/0231440
Number of the records: 1