Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells

Novotná, Božena; Turnovcová, Karolína; Veverka, Miroslav; Rössner ml., Pavel; Bagryantseva, Yana; Herynek, V.; Syková, Eva; Jendelová, Pavla

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Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells

1.

SYSNO ASEP	0425607
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	Biological effects of CZF (cobalt zinc ferrite) nanoparticles in rat bone marrow mesenchymal stem cells
Author(s)	Novotná, Božena (UEM-P) Turnovcová, Karolína (UEM-P)_ORCID Veverka, Miroslav (FZU-D)_RID Rössner ml., Pavel (UEM-P)_{RID, ORCID} Bagryantseva, Yana (UEM-P) Herynek, V. (CZ) Syková, Eva (UEM-P)_RID Jendelová, Pavla (UEM-P)_{RID, ORCID}
Source Title	2nd QNano Integrating Conference. -, 2013 S. 160-160
Number of pages	1 s.
Action	QNano Integrating Conference /2./
Event date	27.02.2013-01.03.2013
VEvent location	Praha
Country	CZ - Czech Republic
Event type	WRD
Language	eng - English
Country	CZ - Czech Republic
Keywords	safety ; cobalt zinc ferrite ; contrast agent ; cell labeling
Subject RIV	FP - Other Medical Disciplines
R&D Projects	GAP304/12/1370 GA ČR - Czech Science Foundation (CSF)
Institutional support	FZU-D - RVO:68378271 ; UEM-P - RVO:68378041
Annotation	To monitor the fate of transplanted cells within the organism, several non-invasive techniques have been introduced, including magnetic resonance imaging (MRI) of cells labeled with a contrast agent prior to grafting. Our previous study demonstrated a severe oxidative injury to lipids, proteins and DNA of human bone marrow mesenchymal stem cells as a result of their labeling with superparamagnetic iron oxide nanoparticles (SPIONs). CZF nanoparticles represent another type of contrast agent based not only on iron, but also on cobalt and zinc (Co0.5Zn0.5Fe2O4+γ), with a ferrite core encapsulated by amorphous silica. The present study was performed with the aim of determining the safe concentration of CZF nanoparticles with respect to oxidative damage to biological macromolecules.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2014

Number of the records: 1