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Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels
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SYSNO ASEP 0420960 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels Author(s) Neckář, Jan (FGU-C) RID, ORCID
Borchert, Gudrun H. (FGU-C)
Hloušková, P. (CZ)
Míčová, P. (CZ)
Nováková, O. (CZ)
Novák, F. (CZ)
Hroch, M. (CZ)
Papoušek, František (FGU-C)
Ošťádal, Bohuslav (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAISource Title Current Pharmaceutical Design - ISSN 1381-6128
Roč. 19, č. 39 (2013), s. 6880-6889Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords chronic continuous hypoxia ; reoxygenation ; ischemia/reperfusion ; myocardial infarction ; potassium channels ; oxidative stress Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects IAAX01110901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA305/07/0875 GA ČR - Czech Science Foundation (CSF) GAP303/12/1162 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000327730800007 EID SCOPUS 84889021388 DOI 10.2174/138161281939131127115154 Annotation The purpose of the study was to assess the impact of brief daily reoxygenation during adaptation to chronic continuous hypoxia on protective cardiac phenotype. The results suggest that chronic continuous hypoxia is cardioprotective and brief daily reoxygenation blunts its salutary effects, possibly by a mechanism involving oxidative stress and attenuation of the activation of mitochondrial BKCa channels Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
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