Association between Tyrosine Hydroxylase Polymorphisms and Left Ventricular Structure in Young Normotensive Men

0404781 - UIVT-O 20020188 RIV GB eng J - Journal Article
Linhart, A. - Jindra, A. - Goláň, L. - Jáchymová, M. - Sedláček, K. - Peleška, Jan - Umnerová, V. - Bultas, J. - Horký, K. - Aschermann, M.
Association between Tyrosine Hydroxylase Polymorphisms and Left Ventricular Structure in Young Normotensive Men.
British Journal of Biomedical Science. Roč. 59, č. 2 (2002), s. 90-94. ISSN 0967-4845
R&D Projects: GA ČR GA305/00/1646; GA MZd NA5615
Keywords : catecholamines * polymorphism (genetics) * tyrosine 3-monooxygenase * ventricular structure, left
Subject RIV: BB - Applied Statistics, Operational Research
Impact factor: 0.953, year: 2002

Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine synthesis. Compared with the VV and VM genotypes of Val-81-Met TH gene polymorphism (PM) young normotensive male subjects with the MM genotype showed significantly increased LV cavity diameter, global LV mass and index. No differences were seen between the subgroups in parameters of LV function, plasma epinephrine and norepinephrine. It suggests an important role for genetic determination of the sympathetic system in LV growth.
Permanent Link: http://hdl.handle.net/11104/0125015