The relevance of monitoring of antibodies against the polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD)

0395363 - ÚEM 2014 RIV SK eng J - Journal Article
Pauk, N. - Klimešová, Š. - Kára, J. - Topinka, Jan - Lábaj, J.
The relevance of monitoring of antibodies against the polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD).
Neoplasma. Roč. 60, č. 2 (2013), s. 182-187. ISSN 0028-2685. E-ISSN 1338-4317
R&D Projects: GA MŠMT 2B06150
Institutional support: RVO:68378041
Keywords : polycyclic aromatic hydrocarbons * anti-PAH antibodies * DNA adducts
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 1.642, year: 2013

The results of a serological epidemiological study aimed at monitoring the levels of anti-PAH antibodies and antibodies to PAH-DNA adducts in serum are presented. The studied groups were both subjects with known lung disease (COPD and lung cancer), as well as healthy population of people working or living at the place with expected increased exposure to PAHs. There has also been proved the relevance of still commonly used markers (DNA adducts) and the suitability of new markers as anti-BPDE-DNA and anti-B(a)P IgA antibodies that provide information on exposures to contaminating components of the environment and their effects on the organism.
Permanent Link: http://hdl.handle.net/11104/0223423