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New insight into transcription of human endogenous retroviral elements
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SYSNO ASEP 0394696 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title New insight into transcription of human endogenous retroviral elements Author(s) Pačes, Jan (UMG-J) RID, ORCID
Huang, Y.T. (TW)
Pačes, Václav (UMG-J) RID
Rídl, Jakub (UMG-J) ORCID
Chang, C.M. (TW)Source Title New Biotechnology. - : Elsevier - ISSN 1871-6784
Roč. 30, č. 3 (2013), s. 314-318Number of pages 5 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords HERV ; transcription ; tissue-specific Subject RIV EB - Genetics ; Molecular Biology R&D Projects GCP305/10/J052 GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 UT WOS 000317240000010 DOI 10.1016/j.nbt.2012.11.009 Annotation It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called ‘junk DNA’. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2013
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