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Novel antimicrobial peptides
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SYSNO ASEP 0394191 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Novel antimicrobial peptides Author(s) Monincová, Lenka (UOCHB-X)
Čeřovský, Václav (UOCHB-X) RID, ORCID
Slaninová, Jiřina (UOCHB-X)
Hovorka, Oldřich (UOCHB-X)
Cvačka, Josef (UOCHB-X) RID, ORCID
Voburka, Zdeněk (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Borovičková, Lenka (UOCHB-X)Number of authors 8 Year of issue 2013 Publication form Online - E Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. EP2396020 Date of the patent acceptance 06.03.2013 Name of the patent owner Ústav organické chemie a biochemie Akademie věd ČR, v. v. i Code of the issuer name EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/ Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Language eng - English Keywords antimicrobial peptides ; bee venom ; hemolytic activity ; NMR spectroscopy ; CD spectroscopy Subject RIV CE - Biochemistry R&D Projects GA203/08/0536 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) Annotation The invention involves two novel peptides of the formulas H-Gly -Met-Trp -Ser-Lys-Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 (I) and H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 (II) isolated from venom reservoirs of primitively eusocial bees Halictus sexcintus and their synthetic analogs possessing biological effects, prepared by the substitution of an amino acid in position 4, 11 or 12 of formula (I) or in position 4 of formula (II) by an amino acid lysine. Described is also their usage for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2014 Electronic address http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20130306&DB=EPODOC&locale=en_EP&CC=EP&NR=2396020B1&KC=B1&ND=4
Number of the records: 1