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Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines
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SYSNO ASEP 0388747 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Isotope exchange reactions of the hydrogen H-5 of selected pyrimidine derivatives and the preparation of tritium-labeled pyrimidines Author(s) Dračínský, Martin (UOCHB-X) RID, ORCID
Jansa, Petr (UOCHB-X) RID
Elbert, Tomáš (UOCHB-X) RID, ORCIDNumber of authors 3 Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 76, č. 12 (2011), s. 1567-1577Number of pages 11 s. Language eng - English Country CZ - Czech Republic Keywords isotopic labeling ; NMR spectroscopy ; nucleobases ; pyrimidines Subject RIV CC - Organic Chemistry R&D Projects KJB400550903 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000299816100010 DOI 10.1135/cccc2011101 Annotation The hydrogen-to-deuterium isotope exchange reaction of hydrogen in position 5 of pyrimidine derivatives was studied using NMR techniques. The dependence of the reaction rate on the pH and on the solvent composition was explored. In tracer experiments using tritiated water, the application of this exchange reaction was tested for the preparation of pyrimidine derivatives labeled by tritium. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2013
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